Macrophage-Derived Chemokine (CCL22) Is a Novel Mediator of Lung Inflammation Following Hemorrhage and Resuscitation

Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes

BACKGROUND CC chemokine ligand 17 (CCL17) and CCL22 are the functional ligands for CCR4. We previously reported that inhibitors of nuclear factor-kappa B and p38 mitogen-activated protein kinase (p38 MAPK), but not of extracellular signal-related kinase (ERK), inhibited tumor necrosis factor (TNF)-α- and interferon (IFN)-γ-induced production of CCL17 by the human keratinocyte cell line, HaCaT. ...

Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a chronically progressive interstitial lung disease of unknown etiology. Previously, we have demonstrated the selective upregulation of the macrophage-derived chemokine CCL22 and the thymus activation-regulated chemokine CCL17 among chemokines, in a rat model of radiation pneumonitis/pulmonary fibrosis and preliminarily observed an increase in b...

Secretion from Basophils Macrophage-Derived Chemokine (CCL22) Overproduction of IgE Induces

17 -Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage

Frink M, Thobe BM, Hsieh Y-C, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. 17 -Estradiol inhibits keratinocytederived chemokine production following trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol 292: L585–L591, 2007. First published November 3, 2006; doi:10.1152/ajplung.00364.2006.—Neutrophil infiltration is a key step in the development of organ dysfunction following trauma-hemorrha...

17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage.

Neutrophil infiltration is a key step in the development of organ dysfunction following trauma-hemorrhage (T-H). Although we have previously shown that 17beta-estradiol (E2) prevents neutrophil infiltration and organ damage following T-H, the mechanism by which E2 inhibits neutrophil transmigration remains unknown. We hypothesized that E2 prevents neutrophil infiltration via modulation of kerat...